Profhilo is a skin-renewing injectable treatment that has quickly become one of the most popular non-surgical cosmetic procedures to address skin laxity and all signs of aging.

Invented in Italy, Profhilo quickly gained traction within the UK in 2015. Winner of Product Innovation of the Year, 2016 at The Aesthetics Awards, it has been popular ever since.

But even if you’ve heard about it, do you know what it does exactly? How is it different from botulinum toxin injections or other types of fillers? Who is suitable for it?

In this post, we will fill you in on everything you need to know about Profhilo, the most talked-about skin-renewing injectable and one of the top 5 facial aesthetic treatments for the better version of ourselves.

What is Profhilo?

Profhilo is an injectable treatment containing one of the highest concentrations of stabilised hyaluronic acid available on the cosmetic surgery market. It is known as a skin remodelling treatment and is specially formulated to target skin laxity and fight the crepe-like texture of ageing skin.

Essentially, Profhilo is a skin-renewing injectable moisturiser that uses the power of hyaluronic acid to stimulate the production of collagen and elastin and boost hydration in the three main layers of skin. This, in turn, reduces fine lines, wrinkles, dullness, and sagginess, and promotes firmer and overall fresher-looking skin from the inside out.

A Word on Hyaluronic Acid

Hyaluronic acid (HA) is produced naturally by our bodies. Despite its name “acid”, hyaluronic acid is actually a type of sugar that binds with water to create a substance with a gel-like consistency. Our body then uses it to lubricate joints, as well as to maintain a good balance of moisture in the skin.

In fact, half of our body’s hyaluronic acid can be found in the skin, mostly within the deeper layers of the dermis. It is thanks to this substance that your skin looks full, healthy, and glowing.

Unfortunately, our body’s production of hyaluronic acid decreases with time, which causes the skin to lose elasticity and wrinkles to appear.

hyaluronic acid profhilo

This knowledge has led to hyaluronic acid becoming a key element of anti-ageing skincare routines and treatments in recent years, from anti-ageing serums to topical skin creams to face fillers, injectables, and so on.

How Does Profhilo Work?

Profhilo uses a pure form of synthetic hyaluronic acid which gets injected strategically into the upper layers of the skin using a very small needle.

Profhilo can be administered in a number of different ways, although the most common and effective method is to use the BAP (bio aesthetic points) technique. This technique works by injecting five key areas on each side of the face, starting with each side just next to the ears, then on to the nasolabial fold, chin, under the eyes, and on the tops of the cheeks.

Once injected into the skin, hyaluronic acid disperses quickly beneath the skin. There is no need for massaging the area during and/or after the treatment nor is there a risk of leaving lumps or nodules.

The downtime following the treatment is minimal, and you are able to return to normal daily activities immediately after the procedure. Just avoid sun or UV light exposure, sports, strenuous physical activities, as well as saunas or hot steamy baths during the first few days post-treatment.


While Profhilo is immediately absorbed deep into the skin, it continues to restore and rejuvenate skin 24/7 from the inside out.

One week after the treatment, you’ll start noticing the skin hydration benefits. Skin feels more plump and smooth. After four weeks, you’ll see the bio-remodelling, and anti-ageing effects. Cheeks are lifted, fine lines are improved, skin feels tighter and looks more luminous and radiant.

The effects of Profhilo tend to naturally wear off after a year. To maintain results, a course of two treatments can be repeated every six months or as needed.

Skin-Renewing Injectables: Why Profhilo is Different

Hyaluronic acids dermal fillers such as JUVÉDERM and Restylane are clear sterile gels contained in a syringe ready for injection. They are made of hyaluronic acid manufactured usually through fermentation and cross-linking with proteins. They work by penetrating into the skin to create volume by drawing in water for an instant filling effect that lasts over around six months.

Nina Bal uses filler for several different treatments:

  • To correct or enhance facial contours; cheeks, temples, jawline, nose, chin
  • To define, correct or enhance lips
  • To soften and correct facial wrinkles or folds
  • To restore lost volume in hands to reduce the appearance of veins and tendons
  • To correct hollows under the eyes (tear troughs)
  • To improve the tone, texture and hydration of the skin

On the other hand, Profhilo treatment is a skin remodelling (or bio remodelling) treatment that intervenes:

  • In the physiological process of ageing tissue, in presence of alterations in elastic fibres and collagen.
  • In the dermal tissue repair process, in cases of acne or scars.
  • In case of loss or compromised adipose tissue.

Rather than plumping and filling wrinkles like dermal fillers, the slow release of hyaluronic acid stimulates the production of collagen and elastin which results in improved skin tone, texture, hydration, and appearance of fine lines.

This effect takes place within 3-5 days post-treatment. The treatment is typically administered over the course of two sessions, four weeks apart. Once results are achieved, a course of two treatments can be repeated every six months or as needed, to maintain the results.

Profhilo can be used in combination with other injectables such as botulinum type A toxin and dermal fillers, or as a stand-alone treatment.

Nina Bal emphasises that Profhilo is not a filler, it doesn’t add any volume and doesn’t change your features. Instead, it reverses the signs of ageing in your skin to give you an amazing dose of instant hydration and stimulate new collagen production.

book a consultation facial sculpting nina bal

So if your goal is to correct other signs of ageing such as pigmentation, melasma, or blemishes, Profhilo alone will not be adequate.

Remember to always book an initial consultation with Nina Bal to thoroughly assess your skin’s specific needs before undergoing any treatments.

Profhilo FAQs

What is Profhilo made of?

Profhilo is a sort of hybrid dermal filler, comprised of non-crosslinked molecules of two types of hyaluronic acid. Each type has a different molecular weight, allowing for the most comprehensive, effective treatment.

How does it work?

This stabilised highly concentrated hybrid of hyaluronic acid releases slowly and evenly under the skin. This fuels the stimulation of collagen and elastin, substances that are responsible for skin laxity, structure, and hydration. It also helps repair scars and blemishes over time.

What is a bio-remodelling treatment?

Bio-remodelling is the process that happens underneath the skin to trigger new collagen and elastin production. Collagen and elastin help fight the signs of ageing skin such as lines and wrinkles, and dull, thinning skin. They also assist with improving skin laxity and encourage overall skin rejuvenation.

What should I expect from the treatment?

Profhilo is done over two sessions, four weeks apart, with little-to-no downtime. Each treatment involves just 10 jabs (five on each side) across the face, from the upper cheekbone to the jawline and chin. This can also be done across the neck or hands if those are your areas of concern.

Are there any side effects of Profhilo?

There is no known risk associated with Profhilo. Minor skin irritations, bruising, or swelling common with injections usually disappear within a day. This treatment is not recommended for women who are pregnant or breastfeeding or people who have allergies to hyaluronic acid.

Top 5 Facial Aesthetic Treatments For The Better Version Of Ourselves

What areas can be treated with Profhilo?

The most common areas of treatment are the face and neck, however, can also be performed on décolletage/cleavage/lower neck, chest, hands, arms, knees, and feet.

How long does the treatment take to do?

Profhilo treatment usually takes around 30 minutes per session to be completed. During this half-hour period, the practitioner will apply numbing cream, mark out spots for injections, and will inject your area of concern in five specific places on both sides of your face.

Who is suitable for this treatment?

Anyone who presents signs of skin ageing (dull, sagging skin, volume loss, fine lines and wrinkles, skin laxity and crepe-like texture, etc.) and is suitable for dermal filler treatments is also suitable for treatment with Profhilo.

What are the benefits of Profhilo?

Benefits of Profhilo include increased firmness, elasticity, improved quality of skin tone, texture, hydration, and overall radiance.

How is Profhilo different from fillers and other wrinkle treatments?

Profhilo is a skin-renewing injectable moisturiser with skin remodelling benefits, reversing signs of ageing like skin laxity and loss of elasticity. It works on skin quality rather than muscle movement which causes wrinkles (like botulinum, does) and doesn’t add any volume as fillers do. Finally, the hydration benefits of Profhilo are much more pronounced as the concentration of hyaluronic acid is higher compared to other types of injectables.

How long does Profhilo last?

Typically, patients find the best results by repeating Profhilo treatments anywhere from six to twelve months.

Profhilo Skin-Renewing Injectable: Conclusions

Profhilo is certainly one of the most buzzed-about non-surgical treatments in recent years, and for good reasons!

Suitable for pretty much everyone, from patients in their late 20s onwards, Profhilo not only tackles signs of ageing without changing your facial features, but it’s also a good skin investment to future-proof your skin.

If you are younger and would like to age-proof your skin by building up the hyaluronic acid, collagen and elastin reserves in your skin, Profhilo is a good consideration to start on early to age gracefully.

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